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ALZET滲透泵在實(shí)際應(yīng)用上具有以下八大優(yōu)點(diǎn)
發(fā)布時(shí)間： 2020-05-22 點(diǎn)擊次數(shù)： 1682次ALZET滲透泵是一種小型、可植入式的膠囊，可應(yīng)用于小鼠、大鼠及其他實(shí)驗(yàn)動(dòng)物研究。該膠囊無需進(jìn)行外部連接或頻繁處理，就能以恒定的速率持續(xù)給藥到四周的時(shí)間。ALZET滲透泵主要由藥物、半透膜材料、滲透壓活性物質(zhì)和推動(dòng)劑組成。ALZET滲透泵片是在片芯外包被一層聚合物構(gòu)成的半透性衣膜，用激光在片劑衣膜層上開一個(gè)或多個(gè)適宜大小的釋藥小孔而制成。口服后，胃腸道內(nèi)的水分通過半透膜進(jìn)入片芯，因滲透壓活性物質(zhì)使膜內(nèi)溶液呈高滲，膜內(nèi)外存在的滲透壓使水分繼續(xù)進(jìn)入膜內(nèi)，從而使藥物溶液或混懸的藥物從小孔泵出。常用的半透膜材料為醋酸纖維素。滲透壓活性物質(zhì)起調(diào)節(jié)藥室內(nèi)滲透壓的作用，其用量與零級(jí)釋藥時(shí)間長(zhǎng)短有關(guān)，常用氯化鈉、乳糖、果糖、葡萄糖、甘露糖等。推動(dòng)劑能吸水膨脹，將藥物層的藥物推出釋藥小孔，常用高分子量聚乙二醇等。除上述組成，ALZET滲透泵片中還可以加入助懸劑、黏合劑、潤(rùn)滑劑、潤(rùn)濕劑等。優(yōu)點(diǎn)：1、可以向幾乎任何組織用藥；2、性價(jià)比很高的研究工具；3、提供了動(dòng)物慢性定量給藥的簡(jiǎn)單方法；4、解決了夜間及周末給藥的不便困擾；5、減少了對(duì)實(shí)驗(yàn)動(dòng)物的操作和應(yīng)激影響；6、足夠小到可以應(yīng)用到小鼠，及年幼大鼠；7、可以執(zhí)行短效期的蛋白質(zhì)及縮氨酸給藥；8、確保連續(xù)不斷得暴露在預(yù)定水平的測(cè)試藥物下。
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